What is amyloidosis in dogs and cats?

Amyloidosis is a condition in which abnormal protein deposits accumulate in the organs, potentially impairing liver and kidney function. Veterinary examination and ongoing monitoring are required; management follows your vet's recommendations.

How does a vet diagnose amyloidosis?

Diagnosis typically begins with blood work, biochemistry panels, and urinalysis, followed by imaging (ultrasound, CT) and tissue biopsy when necessary for confirmation. Follow your vet's guidance on which tests are appropriate.

Does amyloidosis affect my pet's prognosis?

Prognosis varies depending on the organs affected and the extent of protein deposition. Some patients can be managed with supportive care and regular monitoring — discuss an individualised care plan with your vet.

What information should I prepare before the appointment?

Record the onset and progression of symptoms, daily food intake, water consumption, and urination. Bring weight records, a list of current medications, and any photos or videos of symptoms to help the vet assess your pet.

How much do the tests and treatment usually cost?

Costs vary by clinic and region — ask your vet for an estimate before proceeding.

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Disease Guide

Amyloidosis in Dogs & Cats: Symptoms, Diagnosis & Treatment Guide [2025]

Amyloidosis is a disease caused by abnormal protein deposits that damage organs, requiring long-term monitoring and supportive treatment

Take 1 minute to check the symptoms first

Last updated: 2026/01/05

Pethealthmap Editorial Team

Sources: ACVIM, ISFM, National Taiwan University Veterinary Hospital

When to See a Vet

Seek immediate veterinary care (emergency)

•Persistent extreme lethargy with inability to stand on its own
•Persistent vomiting, unable to eat all day, and low energy
•Markedly pale gums or signs of severe dehydration

Schedule a veterinary visit soon (within 24–72 hours)

•Persistently reduced appetite for more than two days
•Markedly increased water intake and frequent urination but still reasonably alert
•Ongoing weight loss or noticeable wasting over more than a week

01What Symptoms Indicate a Problem?

Amyloidosis often causes gradual changes in organ function. Symptoms can be easy to overlook or mistaken for other chronic conditions, and commonly present as changes in energy and appetite, vomiting, weight loss, and abnormal urination.

Persistent lethargy or noticeably reduced activity
Significant decrease in appetite or increased pickiness with food
Repeated vomiting or frequent episodes of vomiting over a short period
Gradual weight loss and visibly lean body condition
Increased water intake or changes in urination frequency (polyuria and polydipsia)
If any of the above signs are present, an early veterinary consultation is recommended

02How to Assess Abnormalities at Home? Key Observations and When to Seek Emergency Care

Observing and recording key changes at home before the vet visit can help your veterinarian quickly assess the progression and urgency of the condition.

Note changes in energy and activity level, and when the signs were first observed
Weigh and record your pet daily to track the rate of weight loss
Log vomiting episodes: frequency, timing, content, and whether blood is present
Measure and record daily water intake and urination frequency
Capture video or photos of symptoms (e.g. walking, vomiting, or urinating)
Bring these records and any samples (vomit or urine) to the appointment

03How Will the Vet Make a Diagnosis? Common Diagnostic Tests

Your vet will use blood tests, urinalysis, imaging, and if necessary, tissue sampling to assess organ involvement and protein deposition, then arrange follow-up or referral accordingly.

Full physical examination to assess overall condition and hydration status

Complete blood count and serum biochemistry panel to evaluate liver, kidney, and other organ function

Urinalysis and urine protein assessment to evaluate kidney function and abnormal protein loss

Abdominal ultrasound to assess organ structure and identify potential deposits or abnormalities

Tissue biopsy when needed to confirm amyloid deposits

Advanced imaging (e.g. CT scan) used in complex cases or when more detailed information is required

Follow-up monitoring or specialist referral recommended based on diagnostic findings

04What Treatment and Care Is Needed After Diagnosis? Medications, Diet, and Home Care Guide

Treatment focuses on managing symptoms and preserving organ function through tailored supportive therapy, with regular check-ups to monitor response and disease progression.

Hospitalisation with intravenous fluid support when needed to address dehydration
Medications and supportive care adjusted according to individual condition, with regular follow-up appointments
Dietary modifications or nutritional support as advised by your vet to maintain body condition
Monitor changes in appetite, vomiting, and elimination at home
Regular blood and urine tests to monitor organ function and treatment effectiveness
Referral to a specialist hospital considered if the condition is complex or advanced diagnostics are needed

05What to Prepare Before the Vet Visit? Key Information to Help the Vet Quickly Identify the Cause

Note the onset of symptoms, how they have changed over time, and the circumstances when first noticed

Prepare a daily log of food intake, water consumption, and urination frequency

Bring recent weight records or the day-of measurement

List all current medications, supplements, and their dosages

If possible, collect a vomit or fresh urine sample to bring to the appointment

Bring any videos, photos, and written records to assist the vet with assessment

This content is for reference only and cannot replace a professional veterinary diagnosis. If your pet shows signs of illness, please seek veterinary care promptly.

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