Disease Guide

Staphylococcal Infection in Dogs & Cats: Symptoms, Diagnosis & Care [2025]

Bacterial skin infection requiring antibiotic treatment

Last updated: 2026/01/06
PetHealthMap Editorial Team
Sources: AVMA, WSAVA, National Taiwan University Veterinary Hospital

When to See a Vet

Seek Emergency Care Immediately

  • Persistent high fever lasting more than 24 hours accompanied by lethargy
  • Large amounts of pus continuously draining from a wound
  • Sudden collapse, unresponsiveness, or inability to stand

Schedule a Clinic Visit Soon (within 24–72 hours)

  • Noticeably reduced appetite with days of not eating or eating very little
  • Persistent redness and swelling of the skin with repeated scratching or biting
  • Changes in elimination such as diarrhea or significantly abnormal urine output

01What symptoms indicate something is wrong?

Staphylococcal infection most commonly presents with skin and mucous membrane symptoms, and may also cause general systemic illness. The following are common warning signs and clinical presentations.

  • Noticeably reduced appetite or refusal to eat
  • Persistent or recurring fever and lethargy
  • Repeated scratching, skin redness, swelling, or oozing sores
  • Localised pain — pet flinches or pulls away when touched
  • Red, swollen eyes with discharge or signs of discomfort
  • Seek veterinary care promptly if any of the above signs worsen or persist

Seek emergency care immediately if you notice the following symptoms:

  • ⚠️ If your pet shows systemic illness or a wound with heavy purulent discharge, seek emergency veterinary care immediately

02How to assess the situation at home — observation checklist and criteria for seeking emergency care

Monitoring key indicators at home and keeping a record helps your vet quickly assess the condition and track the response to treatment.

  • Track appetite and record how much your pet eats at each meal
  • Measure body temperature daily and note the time and reading
  • Photograph or video the scratching, swollen, or wounded areas
  • Monitor your pet's alertness, activity level, and breathing
  • Note any changes in toileting frequency or the character of urine and faeces
  • If there is no improvement within 24–48 hours or symptoms worsen, see a vet

03How will the vet diagnose this? Common diagnostic tests

Your vet will combine clinical examination with laboratory tests to identify the source of infection, determine severity, and assess for concurrent disease.

Physical and skin examination

assessing the extent of involvement and degree of pain

Blood biochemistry and complete blood count

checking for systemic inflammation or organ involvement

Urinalysis

ruling out urinary tract infection or systemic changes

Cytology or tissue biopsy

evaluating local infection or inflammatory cells

Bacterial culture and sensitivity testing (performed as indicated)

04Treatment and home care after diagnosis — medication, diet, and nursing guidance

Treatment focuses on controlling infection, relieving symptoms, and addressing the primary lesion. Regular follow-up is essential to ensure stable recovery.

  • Oral or topical medication and wound management based on test results
  • Dietary adjustment to maintain nutrition, and keeping the skin clean and dry
  • Record body temperature and wound changes daily at home
  • Attend follow-up appointments as recommended by your vet to assess treatment response
  • If symptoms recur or treatment is not effective, referral to a specialist hospital may be advised

05What to prepare before the vet visit — key information to help your vet quickly identify the cause

1
Note when symptoms first appeared, how they have changed, and any worsening
2
List recent foods, treats, and all medications or supplements being given
3
Bring photos or video of the affected area, including close-up shots
4
If possible, bring a fresh urine or faecal sample to the clinic
5
Use a secure carrier and call ahead to make an appointment and describe the situation

This content is for reference only and cannot replace a professional veterinary diagnosis. If your pet shows signs of illness, please seek veterinary care promptly.

Frequently Asked Questions (FAQ)