How is Cushing's syndrome diagnosed in cats?

Your vet will start with a physical examination and blood biochemistry, followed by specific hormone tests and abdominal imaging to evaluate adrenal gland structure. Results are interpreted together to determine if Cushing's syndrome is present. Please consult your veterinarian for details.

Can Cushing's syndrome in cats be treated?

Some cats can be managed with medication or surgery depending on the underlying cause. Treatment planning considers the cat's age and organ function, and long-term monitoring and supportive care are often needed. Follow your vet's recommendations for an individualized plan.

How do I monitor for worsening at home?

Track daily water intake, urination frequency, and weight. If you notice severe lethargy, refusal to eat, or breathing difficulties, seek veterinary attention immediately or contact your vet for advice.

How often does my cat need follow-up appointments?

During initial treatment, frequent blood tests and clinical assessments are often needed every few weeks to months. Once stable, the interval between rechecks may be extended. Your vet will adjust the schedule based on your cat's response.

How much do the tests and treatment usually cost?

Costs vary by clinic and region — ask your vet for an estimate before proceeding.

Disease Guide

Feline Cushing's Syndrome in Cats: Symptoms, Diagnosis & Care Guide [2025]

Hyperadrenocorticism (Cushing's syndrome) is uncommon in cats, presenting with increased thirst, muscle wasting, and fragile skin. Around half of affected cats also have concurrent diabetes mellitus. Diagnosis is complex, and treatment options include medication or surgical removal of the tumor.

Take 1 minute to check the symptoms first

Last updated: 2026/01/05

Pethealthmap editorial team

Sources: ISFM, ACVIM, National Taiwan University Veterinary Hospital

When to See a Vet

Seek immediate veterinary care (emergency)

•Sudden collapse, unresponsiveness, or loss of consciousness
•Severe dehydration, or unable to drink water or eat
•Severe difficulty breathing, or gums turning purple or pale

Schedule a clinic visit as soon as possible (within 24-72 hours)

•Marked increase in water intake and frequent urination
•Increased appetite but clear, ongoing weight loss
•Reduced activity, often appearing lethargic or weak

01What symptoms indicate something is wrong?

Cushing's syndrome in cats often presents with non-specific symptoms that can be difficult to detect early. A veterinary examination is recommended for a thorough evaluation.

Lethargy, sleepiness, or reduced activity level
Increased appetite despite ongoing weight loss
Noticeably increased water intake (polydipsia)
Increased urination frequency or changes in urine volume
Thin body condition despite continued eating
If symptoms persist or worsen, schedule an endocrinology appointment

Seek emergency care immediately if you notice the following symptoms:

⚠️ Sudden collapse, unresponsiveness, or loss of consciousness
⚠️ Severe dehydration, inability to drink or eat
⚠️ Severe breathing difficulty or pale or purple gums

02What should you watch for at home? Key observations and when to seek emergency care

Tracking key data at home helps your vet assess the condition and plan appropriate tests.

Use a measuring cup to record total daily water intake and any changes
Track daily urination frequency and whether it occurs in the usual spot
Weigh your cat at the same time each day and log any changes
Note and record appetite, vomiting, or signs of food selectivity
Record videos of activity, drinking, or urination for your vet's reference
If condition deteriorates rapidly, arrange a veterinary consultation promptly

03How will the vet make a diagnosis? Common diagnostic tests

At the clinic, the vet will perform a physical examination, blood tests, and imaging to assess for an endocrine disorder and rule out other causes.

Physical examination to assess body condition, mucous membrane color, and hydration status

Blood and biochemistry tests to evaluate organ function including kidneys and liver

Specialized endocrine function tests (hormone-related diagnostics)

Abdominal ultrasound to assess adrenal gland and liver structure

Advanced imaging (CT, MRI) or referral to an internal medicine or endocrinology specialist if needed

04What are the treatment and care options? Medication, diet, and home management

Treatment focuses on medical management and supportive care, with regular blood monitoring and clinical follow-up to adjust the treatment plan as needed.

Medical therapy tailored to disease severity, with regular monitoring for side effects
Dietary adjustment and weight management are key components of long-term care
Regular recheck blood tests to monitor hormone levels and organ values
Continue logging symptoms at home to help the vet evaluate treatment response
Referral to an internal medicine specialist is recommended if response is poor or side effects are significant

05What should you bring to the appointment? Key information to help your vet work efficiently

A detailed record of when symptoms started and how they have progressed

A log of daily water intake and urination frequency

Recent weight data, photos, or video files

A complete list of all current medications and nutritional supplements

Any recent blood test results or imaging reports — bring these along to the clinic

This content is for reference only and cannot replace a professional veterinary diagnosis. If your pet shows signs of illness, please seek veterinary care promptly.

Related Symptoms (You May Also Be Looking For)

Hair loss

Enlarged liver

Decreased activity

Abnormal growth

Weak muscles

Frequent urination